Philosophy and Aspirations

The vast majority of catalytic functions in living organisms are achieved by enzymes, which is also one of the most essential components in synthetic biology. From the perspective of synthetic biology to recognize life, its essence is data-driven and designable. Sequence determines the structure, while the structure determines the function, and the computational design of enzyme sequence based on structure is an important research hotspot and frontier field in recent years. This research group is oriented to the demand of creation, mainly carries out the research on the design of new biochemical reactions and the design of new enzymes, and constructs a biocatalyst transformation scheme with wide application and intelligent planning through computer protein design technology, with a view to analyzing and understanding the basic laws of protein catalysis function, and guiding the research and development of a new generation of industrial green catalysts.

Publications Highlights

Empower Microbial Catalysis Through Computation Protein Design.

Nature Catalysis

Development of a versatile and efficient C–N lyase platform for asymmetric hydroamination via computational enzyme redesign.

ACS Catalysis

Computational redesign of a PETase for plastic biodegradation under ambient condition by the GRAPE strategy.